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Disabled homolog 2 is required for migration and invasion of prostate cancer cells

Yinyin Xie,Yuanliang Zhang,Lu Jiang,Mengmeng Zhang,Zhiwei Chen,Dan Liu,Qiuhua Huang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 312-321 doi: 10.1007/s11684-015-0401-3

Abstract:

Disabled homolog 2 (DAB2) is frequently deleted or epigenetically silenced in many human cancerIn this study, DAB2 expression was upregulated along with human prostate cancer (PCa

Keywords： DAB2     prostate cancer     migration     invasion     acetylation    

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Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 11-32 doi: 10.1007/s11684-019-0731-7

Abstract: The human microbiome may influence prostate cancer development.of the human microbiome in relation to prostate cancer risk.Current studies suggest that the microbiota of men with prostate cancer significantly differs from thatcancer.cancer.

Keywords： microbiome     prostate cancer     prevention     treatment     molecular pathological epidemiology (MPE)     biomarker    

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NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: gene is thought to be a tumor-suppressor gene. Our previous study found that overexpression of gene in PC3 cell line could slow down the tumor proliferation rate, associated with a mild decrease in expression. The decrease could increase the sensitivity of radiotherapy to tumors. Thus, we supposed to have an “enhanced firepower” effect by combining overexpressed gene therapy and I radiation therapy uptake by overexpressed hNIS protein. We found a weak endogenous expression of hNIS protein in PC3 cells and demonstrated that the low expression of hNIS protein in PC3 cells might be the reason for the low iodine uptake. By overexpressing in PC3, the radioactive iodine uptake ability was significantly increased. Results of and tumor proliferation experiments and F-fluorothymidine ( F-FLT) micro-positron emission tomography/computed tomography (micro-PET/CT) imaging showed that the combined gene therapy and I radiation therapy mediated by overexpressed hNIS protein had the best tumor proliferative inhibition effect. Immunohistochemistry showed an obvious decrease of expression and the lowest expression. These data suggest that via inhibition of expression, overexpressed might enhance the effect of radiation therapy of I uptake in overexpressed PC3 cells.

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter    

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Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

Grant Perry, Fernando Cortezon-Tamarit, Sofia I. Pascu

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 4-18 doi: 10.1007/s11705-019-1846-8

Abstract: Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer.The detection of the prostate specific antigen (PSA) in blood samples has been the preferred method forthe detection and monitoring of prostate cancer over the past decades.cancer and the detection of its different forms and incorporation in multiplexed designs with otherbiomarkers still remains a highly valuable indicator in the theranostics of prostate cancer.

Keywords： biosensing     immunosensor     PSA     prostate cancer     fluorescence    

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Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 456-463 doi: 10.1007/s11684-014-0353-z

Abstract: can function as tumor suppressors or oncogenes that target many cancer-related genes.miR-200c) on the biological behavior and mechanism of proliferation, migration, and invasion in the prostatecancer cell line Du145.Results showed that DU145 cells exhibited a high expression of miR-200c compared with immortalized normal prostateHence, miR-200c could significantly inhibit the proliferation of the prostate cancer cell line Du145;

Keywords： miR-200c     proliferation     migration     invasion     prostate cancer     Du145 cell     ZEB1    

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Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 231-239 doi: 10.1007/s11684-022-0939-9

Abstract: To evaluate the safety and efficacy of neoadjuvant radiohormonal therapy for oligometastatic prostatecancer (OMPC), we conducted a 3 + 3 dose escalation, prospective, phase I/II, single-arm clinical trial(CHiCTR1900025743), in which long-term neoadjuvant androgen deprivation was adopted 1 month before radiotherapysecondary outcomes were radiological treatment response, positive surgical margin (pSM), postoperative prostate-specificIn all, neoadjuvant radiohormonal therapy is well tolerated for oligometastatic prostate cancer.

Keywords： neoadjuvant     radiotherapy     oligometastatic     prostate cancer     radical prostatectomy    

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Ultrasound-guided prostate percutaneous intervention robot system and calibration by informative particle

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 1,   Pages 3-3 doi: 10.1007/s11465-021-0659-x

Abstract: Applying a robot system in ultrasound-guided percutaneous intervention is an effective approach for prostatecancer diagnosis and treatment.

Keywords： ultrasound image guidance     prostate percutaneous intervention     parallel robot     kinematics identification    

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Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid Article

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

Engineering 2023, Volume 26, Issue 7,   Pages 119-131 doi: 10.1016/j.eng.2023.02.009

Abstract: associations have been found between elevated concentrations of free or conjugated Kdn in relation to human cancerHere, we report for the first time that Kdn is expressed on prostate-specific antigen (PSA) Nprostatecancer (PCa), although no differences were found between PCa and non-PCa patients.

Keywords： Ketodeoxynononic acid     Kdn     Glycosylation     Prostate cancer     Prostate-specific antigen    

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Maximum independent set in planning freight railway transportation

Gainanov Damir N., Mladenovic NENAD, Rasskazova V. A.

Frontiers of Engineering Management 2018, Volume 5, Issue 4,   Pages 499-506 doi: 10.15302/J-FEM-2018031

Abstract: investigation aims to solve the classical combinatorial optimization problem in relation to the maximum independentWith use of these constructions, the lower and upper bounds for the number of vertices in the maximum independent

Keywords： independent set     algorithm     planning of transportation     two-sided estimate    

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Independent cover meshless particle method for complex geotechnical engineering

Jianqiu WU, Yongchang CAI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 4,   Pages 515-526 doi: 10.1007/s11709-017-0428-4

Abstract: A new Independent Cover Meshless Particle (ICMP) method is proposed for the analysis of complex geotechnicalIn the ICMP method, the independent rectangular cover regardless of the shape of the analysis model iseach discrete node, the general polynomial is employed as the meshless interpolation function of the independent

Keywords： meshless method     particle method     independent cover     CTM     geotechnical engineering    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Independent Development：The Way to Build up the Strength of a Country

Jin Lüzhong

Strategic Study of CAE 2005, Volume 7, Issue 7,   Pages 1-6

Abstract:

The paper expounds the significance of independent development in the fields of politics, militaryIt suggests that most of industries in China be provided with the capability of independent developmentThe paper also suggests that the environment favorable to independent development be created in the aspects

Keywords： independent development     goal     possibility    

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Title Author Date Type Operation

Disabled homolog 2 is required for migration and invasion of prostate cancer cells

Yinyin Xie,Yuanliang Zhang,Lu Jiang,Mengmeng Zhang,Zhiwei Chen,Dan Liu,Qiuhua Huang

Journal Article

Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Journal Article

NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article

Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

Grant Perry, Fernando Cortezon-Tamarit, Sofia I. Pascu

Journal Article

Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Journal Article

Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes

Journal Article

Luo Jun: Treatment Selection in Prostate Cancer（2019.8.16）

22 Apr 2021

Conference Videos

Ultrasound-guided prostate percutaneous intervention robot system and calibration by informative particle

Journal Article

Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

Journal Article

Maximum independent set in planning freight railway transportation

Gainanov Damir N., Mladenovic NENAD, Rasskazova V. A.

Journal Article

Huang Jiaoti: Amino Acid Metabolism in Therapeutic Failure and Disease Progression of Prostate Cancer

22 Apr 2021

Conference Videos

Zhang Qing: Proton Heavy Ion Therapy for Prostate Cancer（2019.8.17）

22 Apr 2021

Conference Videos

Independent cover meshless particle method for complex geotechnical engineering

Jianqiu WU, Yongchang CAI

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Independent Development：The Way to Build up the Strength of a Country

Jin Lüzhong

Journal Article